General Information

  • ID:  hor001077
  • Uniprot ID:  NA
  • Protein name:  SKPYMRFamide
  • Gene name:  NA
  • Organism:  Helix aspersa
  • Family:  FMRFamide related peptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  SKPYMRF
  • Length:  7
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T7 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Decrease excitatory responses (depolarization and inward current) evoked by local ionophoretic application of acetylcholine (ACh) onto the soma of identified neurons F1, F2, F4 and F5/6 of the land snail
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001077_AF2.pdbhor001077_ESM.pdb

Physical Information

Mass: 103530 Formula: C43H65N11O10S
Absent amino acids: ACDEGHILNQTVW Common amino acids: FKMPRSY
pI: 10.45 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 1
Hydrophobicity: -105.71 Boman Index: -1868
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 4980 Extinction Coefficient cystines: 1490
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  7789722
  • Title:  Inhibitory Action of SKPYMRFamide on Acetylcholine Receptors of Helix aspersa Neurons: Role of Second Messengers